hepatic artery pump for chemotherapy

  • Hepatic arterial infusion pump chemotherapy for colorectal

    Feb 01 2014  The preferential blood supply from the hepatic artery to crc liver metastases allows for excellent regional delivery of chemotherapy Here we review efficacy and safety data for hepatic artery infusion hai pump chemotherapy in patients with metastatic crc from the 5 fluorouracil era and from the era of modern chemotherapy.

  • Hepatic artery infusion pumps

    The preferential blood supply from the hepatic artery to liver tumors allows for the regional delivery of chemotherapy commonly referred to as hepatic artery infusion chemotherapy via a subcutaneous pump Hepatic artery infusion chemotherapy has been demonstrated to improve overall survival in sele

  • An Update on Hepatic Arterial Infusion Chemotherapy for

    Dec 01 2003  Hepatic arterial infusion HAI chemotherapy delivers high concentrations of cytotoxic agents directly to liver metastases with minimal systemic toxicities Advances in surgical techniques

  • Hepatic Arterial Infusion of Chemotherapy after Resection

    The number of pump related complications was higher in our study than in other studies of hepatic arterial infusion conducted at our center 34 Combining hepatic resection with the pump implant

  • Implantable Infusion Pump

    The response rate was significantly higher in the hepatic arterial infusion group 198 of 461 43 than the systemic chemotherapy group 81 of 440 18 The pooled risk ratio RR was 2.26 95

  • PDF Misperfusion of the liver during hepatic artery

    Misperfusion of the liver during hepatic artery infusion chemotherapy Value of preoperative angiography and postoperative pump scintigraphy May 1993 American Journal of

  • Hepatic Arterial Infusion of Chemo Adult PEDs

    HEPATIC ARTERY INFUSION OF CHEMOTHERAPY Adults Peds 1 I Definition Hepatic arterial infusion HAI of chemotherapy is accomplished by a small drug delivery system or pump that is implanted in a subcutaneous pocket in the lower abdomen The pump reservoir stores and releases prescribed amounts of medication

  • Hepatic Artery Infusion Pump Placement What to Expect at

    A hepatic artery infusion pump is a way to put chemotherapy medicine directly into the liver The pump is used to treat colorectal cancer that has spread to the liver The pump is a small metal container that holds medicine A thin plastic tube called a catheter carries medicine from the pump into a blood vessel that goes to your liver.

  • Hepatic arterial infusion pump chemotherapy for

    The preferential blood supply from the hepatic artery to crc liver metastases allows for excellent regional delivery of chemotherapy Here we review efficacy and safety data for hepatic artery infusion hai pump chemotherapy in patients with metastatic crc from the 5 fluorouracil era and from the era of modern chemotherapy.

  • Treatment of hepatic metastases by transaxillary hepatic

    infusion and intermittent hepatic artery bolus chemo therapy Both the pump refilling and injection of the sideport is done percutaneously using a side hole 22 gauge needle Huber The flow rate is set by the man ufacturer for each pump We have preferred 3 ml/day which allows a two week flow from the 50 ml reservoir between refillings.

  • Perioperative Hepatic Arterial Infusion Pump Chemotherapy

    Perioperative Hepatic Arterial Infusion Pump Chemotherapy is Associated with Longer Survival after Resection of Colorectal Liver Metastases 666.68 KB Rutgers Cancer Institute of New Jersey is the state s only National Cancer Institute designated Comprehensive Cancer Center.

  • Hepatic resection hepatic arterial infusion pump therapy

    the hepatic artery 28 FUDR is therefore an ideal drug for HAI providing a high hepatic concentration of drug with minimal systemic spill over and resultant toxicity The development of an implantable infusion pump allowed for the safe administration of hepatic arterial chemotherapy in the outpatient setting 29 .

  • Hepatic artery infusion therapy is effective for

    Oct 09 2015  Hepatic arterial infusion pump chemotherapy for colorectal liver metastases an old technology in a new era Curr Oncol 201421 116–21 Article Google Scholar Download references Authors’ declaration We attest that the research was performed in accordance with the humane and ethical rules for human experimentation that are stated in the

  • Phase II Study of Hepatic Arterial Infusion Chemotherapy

    This prospective phase II study showed the overall response rate of 67.6 progression free survival of 12.2 months and overall survival of 20.5 months were encouraging for treating advanced perihilar cholangiocarcinoma by means of hepatic arterial infusion chemotherapy with oxaliplatin and 5 fluorouracil via interventionally implanted port catheter.

  • Revisiting Hepatic Artery Infusion Chemotherapy in the

    Hepatic artery infusion chemotherapy HAIC is a well established and common treatment for advanced hepatocellular carcinoma HCC particularly in East Asia However HAIC is not recognized internationally Although several trials have demonstrated the safety and efficacy of HAIC evidence corroborating its overall survival OS benefits compared with standard treatments is insufficient.

  • Combined systemic and hepatic artery infusion pump chemo

    Hepatic artery infusion pump HAIP chemotherapy is an approach which allows direct infusion of chemotherapeutic into the liver and is especially useful in the setting of multifocal liver metastases When combined with systemic chemotherapy HAIP improves the response rate provides more durable disease control and in some patients leads to

  • Hepatic Arterial Infusion Pumps What the Radiologist

    Mar 26 2021  Hepatic arterial infusion HAI entails the surgical implantation of a subcutaneous pump to deliver chemotherapeutic agents directly to the liver in the setting of primary or secondary liver cancer The purpose of HAI chemotherapy is to maximize hepatic drug concentrations while minimizing systemic toxicity facilitating more effective treatment HAI is used in combination with systemic

  • Unravel hepatic artery infusion chemotherapy in patients

    Karanicolas PJ Metrakos P Chan K et al Hepatic arterial infusion pump chemotherapy in the management of colorectal liver metastases expert consensus statement Curr Oncol 201421 e129 36 Gholami S Kemeny NE Boucher TM et al Adjuvant Hepatic Artery Infusion Chemotherapy is Associated With Improved Survival Regardless of KRAS Mutation

  • Chemotherapy

    Hepatic arterial infusion is a method of delivering chemotherapy directly to tumors in the liver It is typically used to treat cancers that have metastasized or spread to this organ A tiny pump is surgically inserted under the skin and connected to the hepatic artery which supplies blood to the liver.

  • Gastric Mucosal lnjury after Hepatic Arterial Infusion

    The effectiveness of hepatic arterial infusion chemo therapy HAIC for primary and metastatic hepatic tu mors is based on hepatic tumors deriving most of their blood supply from the hepatic artery whereas the liver parenchyma is nourished primarily by the portal circu lation An

  • Hepatic Artery Infusion Pump Placement What to Expect at Home

    A hepatic artery infusion pump is a way to put chemotherapy medicine directly into the liver The pump is used to treat colorectal cancer that has spread to the liver The pump is a small metal container that holds medicine A thin plastic tube called a catheter carries medicine from the pump into a blood vessel that goes to your liver.

  • Hepatic Arterial Infusion of Chemotherapy for Metastatic

    The study of hepatic arterial infusion of chemotherapy after resection of hepatic metastases in patients with colorectal cancer reported by Kemeny et al Dec 30 issue 1 represents a positive

  • Intrahepatic Pump Therapy for Metastatic Colon/Rectal

    The pump has thin tubing that goes into a side branch of the hepatic liver artery and delivers chemotherapy or saline directly into the liver Two weeks after surgery the chemotherapy treatment begins Length of procedure About two hours Length of hospital stay Three to four days Surgical Placement of the Intrahepatic Pump

  • Interventionally implanted port catheter systems for

    Aug 09 2013  Hepatic arterial infusion HAI of chemotherapy requires the implantation of a transcatheter application system which is traditionally performed by surgery This procedure but particularly the adjacent drug application via pump or port is often hampered by specific complications and device failure Interventionally implanted port catheter systems IIPCS facilitate the

  • Perioperative Hepatic Arterial Infusion Pump Chemotherapy

    Apr 20 2017  The biologic rationale for hepatic arterial infusion pump chemotherapy HAI is that the hepatic artery rather than the portal vein provides most of the blood supply to CLM 6 Moreover drugs such as floxuridine FUDR have a high first pass extraction in the liver allowing a high dosage in the liver with minimal systemic exposure 7 HAI can

  • Hepatic arterial infusion pump chemotherapy

    Hepatic arterial infusion pump HAIP chemotherapy is an implantable device/port system in the subcutaneous tissue of the anterior abdominal wall and the catheter placed in the hepatic artery It exclusively for the patients with unresectable colorectal liver metastases.

  • STUDY PROTOCOL Open Access Adjuvant hepatic arterial

    Hepatic arterial infusion pump chemotherapy Hepatic arterial infusion pump HAIP chemotherapy using floxuridine for liver tumors is a treatment that has been developed at Memorial Sloan Kettering Cancer Cen ter MSKCC New York USA It is currently not available in the European Union EU because floxuridine FUDR is not registered in the EU.

  • Minimally invasive approaches to hepatic arterial infusion

    this setting that hepatic arterial infusion pump HAIP chemotherapy has emerged as an effective and unique form Ensminger and colleagues by the 1980s transformed hepatic arterial chemotherapy into a truly outpatient treatment Overall rates of mortality for MIS HAIP surgeries are modality 18 Figure 1 .

  • Perioperative Hepatic Arterial Infusion Pump Chemotherapy

    chemotherapy administered in the hepatic artery has been investigated The biologic rationale for hepatic arterial infusion pump chemotherapy HAI is that the hepatic artery rather than the portal vein provides most of the blood supply to CLM.6 Moreover drugs such as floxuridine FUDR have a high first pass extraction in the

  • Article Hepatic Artery Infusion Pump in the Treatment of

    hepatic artery infusion pump and chemotherapy pump The search was limited to accessible full text research articles review articles books and expert content textbooks in English The search dates were not limited but ended January 1 2015 and disciplines outside of

  • Hepatic resection hepatic arterial infusion pump therapy

    An adjunct to resection and/or systemic chemotherapy is the use of hepatic arterial infusion pump HAIP therapy Many studies show HAIP provides benefit for select patients with CRLM Added to the crucible of a multidisciplinary approach to managing CRLM is the ever growing understanding of tumor biology and genetic profiling.

  • Laparoscopic hepatic artery infusion pump

    Laparoscopic hepatic artery infusion pump placement Purpose and Target Group Laparoscopic hepatic artery infusion pump placement is a minimally invasive procedure which enables long term continuous hepatic chemotherapy infusion via an implantable pump in patients with non resectable colorectal liver metastases.

  • Laparoscopic Placement of Hepatic Artery Infusion Pumps

    The rationale for delivering chemotherapy through the hepatic artery HA is that hepatic metastases receive their blood supply mainly from the HA whereas liver parenchyma is primarily supplied by the portal vein.3 Additionally fluorodeoxyuridine FUDR the

  • Hepatic Artery Infusion Pump Chemotherapy A New and

    Aug 26 2021  Hepatic arterial infusion pump chemotherapy is a way to increase chemotherapy dosage to the liver for an improved response Castellanos said The pump can help make surgery an option for more patients which is the only treatment option that offers a chance at long term cure.

  • Case Report Do Hepatic Artery Infusion Pumps Cause

    Hepatic artery infusion pump chemotherapy HAIPC for colorectal liver metastasis CRLM is a relatively new technique Its side effects are not well studied owing to its novelty The purpose of this

  • Hepatic arterial chemotherapy

    The response of liver metastases to systemic combination chemotherapy has improved but the 2 year survival is only 25–30 Hepatic arterial infusion of chemotherapy produces higher response rates